Dr Hakim has co-authored / edited 6 medical books and published chapters in several Rheumatology and General Medicine textbooks. With over 150 original scientific papers, reviews, and book chapters, his research interests include the epidemiology of, and outcomes of treatments in various areas of rheumatic disease. Dr Hakim has also published online learning articles, and worked with television and radio on articles related to the hypermobility syndromes.
Dr Hakim is also an experienced Chief Investigator in phase II and phase III clinical trials, and has a PGCert in Translational Medicine, with a distinction from Edinburgh University.
In September 2018 Dr Hakim was honoured to be appointed Adjunct Associate Professor in Medicine, Pennsylvania State University, USA. And in 2022 Dr Hakim was appointed Hon. Consultant at University College Hospitals London.
Key Books and Chapters
Available online (here).
Dr Hakim’s Book and Key Chapter Publications include:
Books (Editor and Author)
Francomano CA, Hakim AJ, Henderson L, Henderson F (Sr.). Editors. Symptomatic: The symptom-based handbook for EDS and HSD. In Press 2023, Elsevier.
Hakim, A.J., Haq, I., Clunie, G. (2012). The Oxford Handbook of Rheumatology. (3rd ed.) Oxford University Press, Oxford
[And, Hakim, A.J., Haq, I., Clunie, G. (2008). The Oxford Handbook of Rheumatology. (2nd ed.) Oxford University Press, Oxford. Translations into Turkish (2009) and Mandarin ISBN 7-117-07421-3 (2009)
Hakim, A.J., Haq, I., Clunie, G. (2006). The Oxford Handbook of Rheumatology. (1st ed.). Oxford University Press, Oxford]
Hakim, A.J., Keer, R., & Grahame, R. (Eds) (2010). Hypermobility, Fibromyalgia and Chronic Pain (1st ed.). Churchill Livingston, Elsevier.
Sao, P., Hakim, A.J., Haq, I., Clunie, G. (2009) The American Handbook of Rheumatology. (1st ed). Oxford University Press. New York
Pirmohamed, M., Snowden, N., Cropley, I., Hakim, A.J., Barton, A. (2004) MRCP Part 1. Clinical Pharmacology, Immunology, Infectious Diseases, Rheumatology. (1st ed.). Pastest
Patterson, K., Hakim, A. (1997) MRCP Part 1. 100 MCQs on Rheumatology, Immunology, Haematology and Infectious Diseases. (2nd ed.). Pastest
Chapters (Author)
Hakim A.J (2021). Hypermobility Syndromes. In A.W. Watts, P.G. Conaghan, C. Denton, H. Foster, J. Isaacs, U. Muller-Ladner (Eds), The Oxford Textbook of Rheumatology (5th ed.). Commissioned, Oxford University Press.
Grahame, R., Hakim, A.J. & Tofts, L. (2021) Hypermobile Ehlers-Danlos Syndrome, and Hypermobility Spectrum Disorder. In UpToDate, Waltham, MA.
Hakim, A.J., Simmonds, J.V., Kaul, A. (2020). Rheumatology and Postural Tachycardia Syndrome. In N. Gall, L. Kavi, M. Lobo M. (Eds), Postural tachycardia Syndrome (1st ed., pp. 75-92). Springer.
Hakim, A. & Fikree, A. (2015). The Ehlers Danlos Syndrome, and Marfan Syndrome. In R. A. Watts & D. G. I. Scott (Eds), Landmark Papers in Rheumatology (1st ed., pp. 335-355). Oxford University Press.
Grahame. R, Hakim, A.J. (2015). Hypermobility Syndrome. In M.C. Hochberg, A.J. Silman, J.S. Smolen, M.E. Weinblatt, & M.H. Weisman (Eds), Rheumatology (6th ed., pp. 1724-1727). Elsevier Mosby.
Hakim, A.J & Grahame, R. (2013). Hypermobility Syndromes. In A.W. Watts, P.G. Conaghan, C. Denton, H. Foster, J. Isaacs, U. Muller-Ladner (Eds), The Oxford Textbook of Rheumatology (4th ed. pp. 1362-1372). Oxford University Press.
Hakim, A.J. (2010) The Musculoskeletal System. In A.R Houghton & D. Gray (Eds), Chamberlains Symptoms and Signs. (13th ed., pp. 233-253). Hodder Arnold.
Original Scientific Papers and Reviews
2020-Present
Williams H, Hirani S, Wood G, Hakim A, Birchall M. Self-reported throat symptoms in Ehlers-Danlos Syndromes and Hypermobility Spectrum Disorders: A Cross-sectional Survey Study. Laryngoscope Investigative Otolaryngology. Accepted June 2023. DOI: 10.1002/lio2.1120
LJ Tofts, J Simmonds, SB Schwartz, RM Richheimer, C O’Connor, E Elias, R Engelbert, K Cleary, BT Tinkle, AD Kline, AJ Hakim, MAJ van Rossum, Verity Pacey. Pediatric Joint Hypermobility – a Diagnostic Framework and Narrative Review. Orphanet Journal of Rare Diseases. May 2023. https://ojrd.biomedcentral.com/articles/10.1186/s13023-023-02717-2
LN Russek, NP Block, E Byrne, S Chalela, C Chan, M Comerford, N Frost, SHennessy, A McCarthy, LL Nicholson, J Parry, J Simmonds, P Stott, L Thomas, J Treleaven, W Wagner, A Hakim. Presentation and physical therapy management of upper cervical instability in patients with symptomatic generalized joint hypermobility: international expert consensus recommendations. Frontiers in Medicine-Translational Medicine. 18 January 2023. https://doi.org/10.3389/fmed.2022.1072764
Schubart JR, Bascom R, Francomano CA, Bloom L, Hakim AJ. Initial description and evaluation of EDS ECHO: An international effort to improve care for people with the Ehlers-Danlos syndromes and hypermobility spectrum disorders. Am J Med Genet C Semin Med Genet. 2021 Nov 25. doi: 10.1002/ajmg.c.31960.
Hakim AJ, Tinkle BT, Francomano CA. Ehlers-Danlos syndromes, hypermobility spectrum disorders, and associated co-morbidities: Reports from EDS ECHO. Am J Med Genet C Semin Med Genet. 2021 Nov 18. doi: 10.1002/ajmg.c.31954.
Mathias CJ, Owens A, Iodice V, Hakim A. Dysautonomia in the Ehlers-Danlos syndromes and hypermobility spectrum disorders-With a focus on the postural tachycardia syndrome. Am J Med Genet C Semin Med Genet. 2021 Nov 12. doi: 10.1002/ajmg.c.31951.
Bloom L, Schubart J, Bascom R, Hakim A, Francomano CA. The power of patient-led global collaboration. Am J Med Genet C Semin Med Genet. 2021 Nov 6. doi: 10.1002/ajmg.c.31942.
Dhingra R, Hakim A, Bascom R, Francomano CA, Schubart JR. Prescription Claims for Immunomodulator and Anti-Inflammatory Drugs among Persons with Ehlers-Danlos Syndromes. Arthritis Care Res (Hoboken). 2021 Nov 17. doi: 10.1002/acr.24819.
Grahame R, Malik I, Hakim A, Koby M, Henderson F. Comment on “Quantitative measures of tissue mechanics to detect hypermobile Ehlers-Danlos syndrome and hypermobility syndrome disorders: a systematic review”. Clinical Rheumatology. 2020; 39(3) DOI: 10.1007/s10067-020-05192-3
Morlino S, Micale L, Ritelli M., et al. COL1-related overlap disorder: a novel connective tissue disorder incorporating the osteogenesis imperfecta / Ehlers-Danlos syndrome overlap. Clin Genet. 2020 Mar;97(3):396-406
2010-2019
Hakim AJ, Francomano CA, Castori M, Malfait F. Concerns regarding the inference that EDS is not rare. BMJ Open. 2019. Nov 11. bmjopen.bmj.com/open/9/11/e031365
Schubart JR, Schaefer E, Janicki P, Adhikary SD, Schilling A, Hakim AJ, Bascom R, Francomano CA, Raj SR. Resistance to local dental anesthesia in people with the Ehlers-Danlos Syndromes. J Dent Anesth Pain Med. 2019;19(5):261-270.
Schubart JR, Schaefer E, Hakim AJ, Francomano CA, Bascom R. Use of Cluster Analysis to Delineate Symptom Profiles in Ehlers-Danlos Syndrome Patient Population. J Pain Symptom Manage. 2019 Sep;58(3):427-436.
Hakim AJ. Severity classes in adults with hypermobile Ehlers-Danlos syndrome/hypermobility spectrum disorder, Rheumatology (Oxford). 2019 Oct 1;58(10):1705-1706.
Simmonds JV, Herbland A, Hakim A, Ninis N, Lever W, Aziz Q, Cairns M. Exercise beliefs and behaviours of individuals with Joint Hypermobility syndrome/Ehlers–Danlos syndrome – hypermobility type. Journal of Disability and Rehabilitation. 2019 Feb;41(4):445-455.
Castori M, Hakim AJ. 2017. Contemporary Approach to Joint Hypermobility and Related Disorders. Current Opinion in Pediatrics. 2017 Dec;29(6):640-649.
Malfait F, Francomano C, Byers P, et al. The 2017 international classification of the Ehlers–Danlos syndromes. Am J Med Genet Part C Semin Med Genet, 2017;175C:8–26.
Hakim A, de Wandele I, O’Callaghan C, Stiles L, Pocinki A, Rowe P. Cardiovascular Autonomic Dysregulation in Ehlers-Danlos Syndrome – hypermobile type. Am J Med Genet C Semin Med Genet. 2017; 175C:168-174.
Hakim A, O’Callaghan C, De Wandele I, Pocinki A, Rowe P. Chronic Fatigue in Ehlers-Danlos Syndrome – hypermobile type. Am J Med Genet C Semin Med Genet. 2017; 175C:175-180.
Castori M, Tinkle B, Levy H, Grahame R, Malfait F, Hakim A. A framework for the classification of joint hypermobility and related conditions. Am J Med Genet C Semin Med Genet. 2017; 175C:148-157.
Smith TO, de Medici A, Oduoza U, Hakim A, Paton B, Retter G, Haddad FS, Macgregor A. National survey to evaluate musculoskeletal health with retired professional ballet dancers in the United Kingdom. Phys Ther Sport. 2017 Jan;23:82-85.
Arulanandam S, Hakim AJ, Aziz Q, Sandhu G, Birchall MA. Laryngological presentations of Ehlers-Danlos syndrome: case series of nine patients from two London tertiary referral centres. Clin Otolaryngol. 2017 Aug;42(4):860-863.
Smith T, Davies L, de Medici A, Hakim A, Haddad F, Macgregor A. Challenges in reporting systematic reviews on epidemiological sport injury data: letter to the editor re: “Upholding standards of reporting in the synthesis of dance epidemiology literature”. Phys Ther Sport. 2016 Nov;22:131-132.
Smith TO, Davies L, de Medici A, Hakim A, Haddad FS, Macgregor A. Prevalence and profile of musculoskeletal injuries in ballet dancers: A systematic review and meta-analysis. Physical Therapy in Sport. 2016 May;19:50-6.
Connelly E, Hakim A, Davenport HS, Simmonds JV. A study exploring the prevalence of joint hypermobility syndrome in patients attending a musculoskeletal triage clinic. Physiother Pract Res 2015;36:43–53.
Ibrahim F, Choy E, Gordon P, Doré CJ, Hakim A, Kitas G, Isenberg D, Griffiths B, Lecky B, Chakravarty K, Winer J, Danko K, Cooper RG, White-Alao B, Scott DL. Second-line agents in myositis: 1-year factorial trial of additional immunosuppression in patients who have partially responded to steroids. Rheumatology (Oxford). 2015 Jun;54(6):1050-5.
Fikree A, Aktar R, Grahame R, Hakim AJ, Morris JK, Knowles CH, Aziz Q. Functional gastrointestinal disorders are associated with the joint hypermobility syndrome in secondary care: a case-control study. Neurogastroenterol Motil. 2015 Apr;27(4):569-79.
Fikree A, Grahame R, Aktar R, Farmer AD, Hakim AJ, Morris JK, Knowles CH, Aziz Q. A prospective evaluation of undiagnosed joint hypermobility syndrome in patients with gastrointestinal symptoms. Clin Gastroenterol Hepatol. 2014 Oct;12(10):1680-87.
Hakim AJ, Grahame R. Recognizing the scale of joint hypermobility burden: comment on the article by Mulvey et al. Arthritis Care Res (Hoboken). 2014 Mar;66(3):496.
Cordingley L, Prajapati R, Plant D, Maskell D, Morgan C, Ali FR, Morgan A W, Wilson AG, Isaacs JD; Biologics in Rheumatoid Arthritis Genetics and GenomicsStudy Syndicate (BRAGGSS), Barton A. Impact of psychological factors on subjective disease activity assessments in patients with severe rheumatoidarthritis. Arthritis Care Res (Hoboken). 2014 Jun;66(6):861-8.
Yarwood A, Viatte S, Plant D, Morgan AW, Isaacs J, Wilson AG, Hyrich K, Eyre S, Barton A; Biologics in Rheumatoid Arthritis Genetics and Genomics StudySyndicate (BRAGGSS). Testing the role of vitamin D in response to antitumour necrosis factor α therapy in a UK cohort: a Mendelian randomisation approach. AnnRheum Dis. 2014 May;73(5):938-40.
Bluett J, Ibrahim I, Plant D, Hyrich KL, Morgan AW, Wilson AG, Isaacs JD; BRAGGSS, Barton A. Association of a complement receptor 1 gene variant with baseline erythrocyte sedimentation rate levels in patients starting anti-TNF therapy in a UK rheumatoid arthritis cohort: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort. Pharmacogenomics J. 2014 Apr;14(2):171-5.
Grahame R, Hakim AJ. Arachnodactyly–a key to diagnosing heritable disorders of connective tissue. Nat Rev Rheumatol. 2013 Jun;9(6):358-64.
Gabay C, Emery P, van Vollenhoven R, Dikranian A, Alten R, Pavelka K, Klearman M, Musselman D, Agarwal S, Green J, Kavanaugh A; ADACTA Study Investigators. Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): a randomised, double-blind, controlled phase 4 trial. Lancet. 2013 May 4;381(9877):1541-50.
Livshits G, Malkin I, Williams FM, Hart DJ, Hakim A, Spector TD. Longitudinal study of variation in body mass index in middle-aged UK females. Age (Dordr).2012 Oct;34(5):1285-94.
Eyre S, Bowes J, Diogo D, et al., High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nat Genet. 2012 Dec;44(12):1336-40.
Plant D, Ibrahim I, Lunt M, Eyre S, Flynn E, Hyrich KL, Morgan AW, Wilson AG, Isaacs JD; BRAGGSS, Barton A. Correlation of C-reactive protein haplotypes with serum C-reactive protein level and response to anti-tumor necrosis factor therapy in UK rheumatoid arthritis patients: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort. Arthritis Res Ther. 2012 Oct 7;14(5):R214.
Fisher BA, Plant D, Lundberg K, Charles P, Barton A, Venables PJ; Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate (BRAGGSS). Heterogeneity of anticitrullinated peptide antibodies and response to anti-tumor necrosis factor agents in rheumatoid arthritis. J Rheumatol. 2012 May;39(5):929-32.
Ghebre MA, Hart DJ, Hakim AJ, Kato BS, Thompson V, Arden NK, Spector TD, Zhai G. Association between DHEAS and bone loss in postmenopausal women: a 15-year longitudinal population-based study. Calcif Tissue Int. 2011 Oct;89(4):295-302.
Hakim AJ and Gardener P. Work-related Musculoskeletal Injuries and Paintings Conservation. The Picture Restorer. 2011 (38); 36-39.
Rubbert-Roth A, Tak PP, Zerbini C, Tremblay JL, Carreño L, Armstrong G, Collinson N, Shaw TM; MIRROR Trial Investigators. Efficacy and safety of various repeat treatment dosing regimens of rituximab in patients with active rheumatoid arthritis: results of a Phase III randomized study (MIRROR). Rheumatology (Oxford). 2010 Sep;49(9):1683-93.
Wang TJ, Zhang F, Richards JB, Kestenbaum B, van Meurs JB, et al. Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet. 2010 Jul 17;376(9736):180-8.
Zhai G, Wang-Sattler R, Hart DJ, Arden NK, Hakim AJ, Illig T, Spector TD. Serum branched-chain amino acid to histidine ratio: a novel metabolomic biomarker of knee osteoarthritis. Ann Rheum Dis. 2010 Jun;69(6):1227-31.
Hassan B, Maxwell JR, Hyrich KL; Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate, Barton A, Worthington J, Isaacs JD, Morgan AW, Wilson AG. Genotype at the sIL-6R A358C polymorphism does not influence response to anti-TNF therapy in patients with rheumatoid arthritis. Rheumatology (Oxford). 2010 Jan;49(1):43-7.
2000-2009
Bowes JD, Potter C, Gibbons LJ, Hyrich K, Plant D, Morgan AW, Wilson AG, Isaacs JD, Worthington J, Barton A; BRAGGSS. Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients. Pharmacogenet Genomics. 2009 Apr;19(4):319-23.
Briggs J, McCormack M, Hakim AJ, Grahame R. Injury and joint hypermobility syndrome in ballet dancers–a 5-year follow-up. Rheumatology (Oxford). 2009 Dec;48(12):1613-4.
Zhai G, Hart DJ, Valdes AM, Kato BS, Richards JB, Hakim A, Spector TD. Natural history and risk factors for bone loss in postmenopausal Caucasian women: a 15-year follow-up population-based study. Osteoporos Int. 2008 Aug;19(8):1211-7.
Grahame R, Hakim AJ. Hypermobility. Curr Opin Rheumatol. 2008 Jan;20(1):106-10.
Mullin BH, Spector TD, Curtis CC, Ong GN, Hart DJ, Hakim AJ, Worthy T, Wilson SG. Polymorphisms in ALOX12, but not ALOX15, are significantly associated with BMD in postmenopausal women. Calcif Tissue Int. 2007 Jul;81(1):10-7.
Greenwood MC, Rathi J, Hakim AJ, Scott DL, Doyle DV. Regression to the mean using the disease activity score in eligibility and response criteria for prescribing TNF-alpha inhibitors in adults with rheumatoid arthritis. Rheumatology (Oxford). 2007 Jul;46(7):1165-7.
Kuttikat A, Keat A, Hughes R, Hakim A, Chakravarty K. A case of polymyalgia rheumatica, microscopic polyangiitis, and B-cell lymphoma. Nat Clin Pract Rheumatol. 2006 Dec;2(12):686-90.
Hakim AJ, Sahota A. Joint hypermobility and skin elasticity: the hereditary disorders of connective tissue. Clin Dermatol. 2006 Nov-Dec;24(6):521-33.
Malfait F, Hakim AJ, De Paepe A, Grahame R. The genetic basis of the joint hypermobility syndromes. Rheumatology (Oxford). 2006 May;45(5):502-7.
Greenwood MC, Hakim AJ, Doyle DV. A simple extension to the Rheumatoid Arthritis Quality of Life Questionnaire (RAQol) to explore individual patient concerns and monitor group outcome in clinical practice. Rheumatology (Oxford). 2006 Jan;45(1):61-5.
Greenwood MC, Hakim AJ, Carson E, Doyle DV. Touch-screen computer systems in the rheumatology clinic offer a reliable and user-friendly means of collecting quality-of-life and outcome data from patients with rheumatoid arthritis. Rheumatology (Oxford). 2006 Jan;45(1):66-71.
Hakim AJ, Grahame R, Norris P, Hopper C. Local anaesthetic failure in joint hypermobility syndrome. J R Soc Med. 2005 Feb;98(2):84-5.
Zweers MC, Hakim AJ, Grahame R, Schalkwijk J. Joint hypermobility syndromes: the pathophysiologic role of tenascin-X gene defects. Arthritis Rheum. 2004 Sep;50(9):2742-9.
Hakim AJ, Grahame R. Non-musculoskeletal symptoms in joint hypermobility syndrome. Indirect evidence for autonomic dysfunction? Rheumatology (Oxford). 2004 Sep;43(9):1194-5.
Hakim AJ, Cherkas LF, Grahame R, Spector TD, MacGregor AJ. The genetic epidemiology of joint hypermobility: a population study of female twins. Arthritis Rheum. 2004 Aug;50(8):2640-4.
Hakim A, Grahame R. Joint hypermobility. Best Pract Res Clin Rheumatol. 2003 Dec;17(6):989-1004.
Hakim AJ, Cherkas LF, Spector TD, MacGregor AJ. Genetic associations between frozen shoulder and tennis elbow: a female twin study. Rheumatology (Oxford). 2003 Jun;42(6):739-42.
Hakim AJ, Grahame R. A simple questionnaire to detect hypermobility: an adjunct to the assessment of patients with diffuse musculoskeletal pain. Int J Clin Pract. 2003 Apr;57(3):163-6.
Hakim AJ, Cherkas L, El Zayat S, MacGregor AJ, Spector T. The genetic component to carpal tunnel syndrome in women: a twin study. Arthritis Rheumatism. 2002; 47(3): 275-9
Hakim AJ, Machin SJ, Isenberg DA. Autoimmune thrombocytopenia in primary antiphospholipid syndrome and systemic lupus erythematosus: the response to splenectomy. Semin Arthritis Rheum. 1998 Aug;28(1):20-5.
Scientific abstract and Conference publication citations are available on request.
