Dr Alan J Hakim MA FRCP

Consultant in Rheumatology & Acute Medicine

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BRAGGSS Publications 2009-2014

Cordingley L, Prajapati R, Plant D, Maskell D, Morgan C, Ali FR, Morgan  A W, Wilson AG, Isaacs JD; Biologics in Rheumatoid Arthritis Genetics and GenomicsStudy Syndicate (BRAGGSS), Barton A. Impact of psychological factors on subjective disease activity assessments in patients with severe rheumatoidarthritis. Arthritis Care Res (Hoboken). 2014 Jun;66(6):861-8. doi:10.1002/acr.22249. PubMed PMID: 24339425; PubMed Central PMCID: PMC4153952.

Yarwood A, Viatte S, Plant D, Morgan AW, Isaacs J, Wilson AG, Hyrich K, Eyre  S, Barton A; Biologics in Rheumatoid Arthritis Genetics and Genomics StudySyndicate (BRAGGSS). Testing the role of vitamin D in response to antitumour necrosis factor α therapy in a UK cohort: a Mendelian randomisation approach. AnnRheum Dis. 2014 May;73(5):938-40. doi: 10.1136/annrheumdis-2013-204443. Epub 2013 Dec 9. PubMed PMID: 24323394.

Bluett J, Ibrahim I, Plant D, Hyrich KL, Morgan AW, Wilson AG, Isaacs JD; BRAGGSS, Barton A. Association of a complement receptor 1 gene variant with baseline erythrocyte sedimentation rate levels in patients starting anti-TNF therapy in a UK rheumatoid arthritis cohort: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort. Pharmacogenomics J. 2014 Apr;14(2):171-5. doi: 10.1038/tpj.2013.26. Epub 2013 Jul 16. PubMed PMID: 23856853; PubMed Central PMCID: PMC3965567.

Eyre S, Bowes J, Diogo D, et al., High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nat Genet. 2012 Dec;44(12):1336-40. doi:10.1038/ng.2462. Epub 2012 Nov 11. PubMed PMID: 23143596; PubMed Central PMCID:PMC3605761.

Plant D, Ibrahim I, Lunt M, Eyre S, Flynn E, Hyrich KL, Morgan AW, Wilson AG, Isaacs JD; BRAGGGSS, Barton A. Correlation of C-reactive protein haplotypes with serum C-reactive protein level and response to anti-tumor necrosis factor therapy in UK rheumatoid arthritis patients: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort. Arthritis Res Ther. 2012 Oct 7;14(5):R214. doi: 10.1186/ar4052. PubMed PMID: 23039402; PubMed Central PMCID: PMC3580526.

Fisher BA, Plant D, Lundberg K, Charles P, Barton A, Venables PJ; Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate (BRAGGSS). Heterogeneity of anticitrullinated peptide antibodies and response to anti-tumor necrosis factor agents in rheumatoid arthritis. J Rheumatol. 2012 May;39(5):929-32. doi: 10.3899/jrheum.111315. Epub 2012 Apr 1. PubMed PMID:
22467927.

Hassan B, Maxwell JR, Hyrich KL; Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate, Barton A, Worthington J, Isaacs JD, Morgan AW, Wilson AG. Genotype at the sIL-6R A358C polymorphism does not influence response to anti-TNF therapy in patients with rheumatoid arthritis. Rheumatology (Oxford). 2010 Jan;49(1):43-7. doi: 10.1093/rheumatology/kep372. Epub 2009 Nov 19. PubMed PMID: 19926672.

Bowes JD, Potter C, Gibbons LJ, Hyrich K, Plant D, Morgan AW, Wilson AG, Isaacs JD, Worthington J, Barton A; BRAGGSS. Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients. Pharmacogenet Genomics. 2009 Apr;19(4):319-23. doi: 10.1097/FPC.0b013e328328d51f. PubMed PMID:19262425.

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For Existing Patients Dr Hakim’s office email details can be found on their clinic letter.

Postal Address: Dr Alan J Hakim,  PO BOX 53189, London, E18 9DH

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Affiliations

Fellow of the Royal College of Physicians, London

Prior Regional Chair and Member of Council

Member of the British Medical Association

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